Dutta Debayan, Karthik Kulanthaivelu, Holla Vikram V, Kamble Nitish, Yadav Ravi, Pal Pramod Kumar, Mahale Rohan R
Department of Neurology National Institute of Mental Health and Neurosciences Bengaluru India.
Department of Neuroimaging and Interventional Radiology National Institute of Mental Health and Neurosciences Bengaluru India.
Mov Disord Clin Pract. 2023 Apr 6;10(5):794-801. doi: 10.1002/mdc3.13733. eCollection 2023 May.
About 70-90% of Parkinson's disease (PD) patients have olfactory deficits which is considered as pre-motor symptom of PD. Lewy bodies have been demonstrated in the olfactory bulb (OB) in PD.
To assess the OB volume (OBV), olfactory sulcus depth (OSD) in PD and compare with progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and vascular parkinsonism (VP) patients and determine the cut-off volume of OB that will aid in the diagnosis of PD.
This was a cross-sectional, hospital based, single-center study. Forty PD, 20 PSP, 10 MSA, 10 VP patients and 30 controls were recruited. OBV and OSD was assessed using 3-T magnetic resonance imaging (MRI) brain. Olfaction was tested using Indian Smell Identification test (INSIT).
The mean total OBV in PD was 113.3 ± 79.2 mm and 187.4 ± 65.0 mm in controls ( = 0.003) which was significantly lower in PD. The mean total OSD in PD was 19.4 ± 8.1 and 21.1 ± 2.2 mm in controls ( = 0.41) with no difference. The mean total OBV was significantly lower in PD as compared to that of PSP, MSA and VP patients. There was no difference in the OSD among the groups. The total OBV in PD had no association with age at onset, duration of disease, dopaminergic drugs dosage, motor and non-motor symptoms severity but had positive correlation with cognitive scores.
OBV is reduced in PD patients as compared to PSP, MSA, VP patients and controls. OBV estimation by MRI adds to the armamentarium in the diagnosis of PD.
约70 - 90%的帕金森病（PD）患者存在嗅觉减退，这被认为是PD的运动前症状。在PD患者的嗅球（OB）中已证实存在路易小体。
评估PD患者的OB体积（OBV）和嗅沟深度（OSD），并与进行性核上性麻痹（PSP）、多系统萎缩（MSA）和血管性帕金森综合征（VP）患者进行比较，确定有助于PD诊断的OB临界体积。
这是一项基于医院的单中心横断面研究。招募了40例PD患者、20例PSP患者、10例MSA患者、10例VP患者和30名对照者。使用3-T磁共振成像（MRI）脑部扫描评估OBV和OSD。使用印度嗅觉识别测试（INSIT）检测嗅觉。
PD患者的平均总OBV为113.3±79.2 mm，对照组为187.4±65.0 mm（P = 0.003），PD患者的明显更低。PD患者的平均总OSD为19.4±8.1 mm，对照组为21.1±2.2 mm（P = 0.41），无差异。与PSP、MSA和VP患者相比，PD患者的平均总OBV明显更低。各组之间的OSD无差异。PD患者的总OBV与发病年龄、病程、多巴胺能药物剂量、运动和非运动症状严重程度均无关联，但与认知评分呈正相关。
与PSP、MSA、VP患者及对照相比，PD患者的OBV减小。通过MRI估计OBV有助于PD的诊断。
