Araki K, Miyakawa T, Katsuragi S
Department of Neuropsychiatry, Kumamoto University Medical School, Japan.
Jpn J Psychiatry Neurol. 1991 Mar;45(1):85-9. doi: 10.1111/j.1440-1819.1991.tb00510.x.
The subjects used in the present study consisted of 8 cases with Alzheimer's disease. Senile plaques which seemed to have no relation with the capillaries were examined in thick serial sections (3,000-5,000 A) by electron microscope. The results obtained were as follows: All of those senile plaques had amyloid angiopathy with amyloid fibrils and these amyloid fibrils formed the main elements of senile plaques. From these findings, it was confirmed that the amyloid fibrils in all plaques are produced from the capillaries.
本研究使用的对象包括8例阿尔茨海默病患者。通过电子显微镜在厚连续切片（3000 - 5000埃）中检查了似乎与毛细血管无关的老年斑。获得的结果如下：所有这些老年斑都有淀粉样血管病伴淀粉样纤维，并且这些淀粉样纤维构成了老年斑的主要成分。从这些发现可以证实，所有斑块中的淀粉样纤维均由毛细血管产生。
