Kimura T, Hisano T, Ueda K, Miyakawa T
Division of Clinical Research, National KIKUCHI Hospital for Mental and Nervous Diseases, Kumamoto, Japan.
Jpn J Psychiatry Neurol. 1993 Dec;47(4):909-14. doi: 10.1111/j.1440-1819.1993.tb01840.x.
We examined the location of beta-protein deposits (small diffuse plaques) in the cerebral cortices of Alzheimer's patients and aged nondemented controls by observing the methenamine silver stained serial sections. Some vessels, astrocytes or neuronal elements existed near or within the diffuse plaques, and the preamyloids in the plaques were frequently detected in direct contact with vessels, astrocytes or neuronal elements. Although these findings do not demonstrate that the beta-protein within the senile plaques is produced in various cellular elements of the brain, they suggest some associations between beta-protein deposition and vessels, astrocytes or neuronal elements.
我们通过观察六胺银染色的连续切片，研究了阿尔茨海默病患者和老年非痴呆对照者大脑皮质中β蛋白沉积物（小的弥漫性斑块）的位置。在弥漫性斑块附近或内部存在一些血管、星形胶质细胞或神经元成分，并且斑块中的淀粉样前体蛋白经常被检测到与血管、星形胶质细胞或神经元成分直接接触。尽管这些发现并未证明老年斑内的β蛋白是由大脑的各种细胞成分产生的，但它们表明β蛋白沉积与血管、星形胶质细胞或神经元成分之间存在一些关联。
