[组胺对豚鼠呼吸阻力和动态顺应性的影响]
[Changes in respiratory resistance and dynamic compliance induced by histamine in the guinea pig].
作者信息
Aoki S, Tsukagoshi H, Kurosawa M
机构信息
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
出版信息
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Oct;29(10):1239-46.
Respiratory resistance and dynamic compliance in guinea pigs were measured by pulmonary mechanics analyzer Buxco Model 6. Changes induced by intravenous injection of histamine were studied. Administration of histamine caused dose-dependent increase in respiratory resistance and decrease in dynamic compliance in guinea pigs. The increase in respiratory resistance by repeated injections of the same dose of histamine was maintained at the same level 5 hours after the first injection. However, the decrease in dynamic compliance by histamine administration decreased significantly from 1 to 4 hours after the first injection. The baseline resistance increased from 1 to 5 hours after the first injection of histamine. The baseline compliance decreased from 1 to 5 hours after the first injection.
采用Buxco 6型肺力学分析仪测量豚鼠的呼吸阻力和动态顺应性。研究了静脉注射组胺引起的变化。组胺给药导致豚鼠呼吸阻力呈剂量依赖性增加，动态顺应性降低。重复注射相同剂量组胺后，呼吸阻力的增加在首次注射后5小时维持在同一水平。然而，组胺给药引起的动态顺应性降低在首次注射后1至4小时显著下降。首次注射组胺后1至5小时，基线阻力增加。首次注射后1至5小时，基线顺应性降低。
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