Drazen J M, Austen K F
J Clin Invest. 1974 Jun;53(6):1679-85. doi: 10.1172/JCI107719.
The effects of intravenous administration of a purified preparation of slow-reacting substance of anaphylaxis (SRS-A), histamine, bradykinin, and prostaglandin F(2alpha) (PGF(2alpha)) on the mechanics of respiration were assessed in the unanesthetized guinea pig. Geometrically increasing doses of SRS-A resulted in graded decreases in average pulmonary compliance, with only modest increases in average pulmonary resistance. A dose with apparent maximal effects. 3,000 U/kg, resulted in a decrease of 49+/-7% of compliance below control values, with an increase in resistance of 24+/-8% above control. Intravenous administration of geometrically increasing amounts of histamine, bradykinin, and prostaglandin F(2alpha) also resulted in decreased compliance; but in each case this was accompanied by a marked increase in respiratory resistance. A decrease of compliance of approximately 50%, induced by intravenous histamine, bradykinin, or PGF(2alpha), was accompanied by an increase of 60-140% in resistance. Thus, intravenously administered SRS-A alters pulmonary mechanics with a more peripheral effect than any of the other agents tested.
在未麻醉的豚鼠身上评估了静脉注射纯化的过敏反应慢反应物质（SRS-A）、组胺、缓激肽和前列腺素F(2α)（PGF(2α)）对呼吸力学的影响。几何级数增加剂量的SRS-A导致平均肺顺应性分级下降，而平均肺阻力仅适度增加。具有明显最大效应的剂量，即3000 U/kg，使顺应性比对照值降低49±7%，阻力比对照增加24±8%。静脉注射几何级数增加量的组胺、缓激肽和前列腺素F(2α)也导致顺应性降低；但在每种情况下，这都伴随着呼吸阻力的显著增加。静脉注射组胺、缓激肽或PGF(2α)引起的顺应性降低约50%，同时阻力增加60-140%。因此，静脉注射的SRS-A改变肺力学的作用比所测试的任何其他药物都更具外周效应。
