Wong T, McGrath J A, Navsaria H
Division of Genetics and Molecular Medicine, St John's Institute of Dermatology, The Guy's, King's and St Thomas' School of Medicine, London, UK.
Br J Dermatol. 2007 Jun;156(6):1149-55. doi: 10.1111/j.1365-2133.2007.07914.x.
Fibroblasts are mesenchymal cells that can be readily cultured in the laboratory and play a significant role in epithelial-mesenchymal interactions, secreting various growth factors and cytokines that have a direct effect on epidermal proliferation, differentiation and formation of extracellular matrix. They have been incorporated into various tissue-engineered products such as Dermagraft (Advanced BioHealing, La Jolla, CA, U.S.A.) and Apligraf (Novartis, Basel, Switzerland) and used for a variety of clinical applications, including the treatment of burns, chronic venous ulcers and several other clinical applications in dermatology and plastic surgery. In this article we review the cell biology of dermal fibroblasts and discuss past and current experience of the clinical use of cultured fibroblasts.
成纤维细胞是间充质细胞，能够在实验室中轻松培养，并且在上皮-间充质相互作用中发挥重要作用，分泌各种对表皮增殖、分化以及细胞外基质形成有直接影响的生长因子和细胞因子。它们已被纳入各种组织工程产品中，如Dermagraft（美国加利福尼亚州拉霍亚的Advanced BioHealing公司）和Apligraf（瑞士巴塞尔的诺华公司），并用于多种临床应用，包括烧伤治疗、慢性静脉溃疡以及皮肤科和整形外科的其他一些临床应用。在本文中，我们回顾了真皮成纤维细胞的细胞生物学，并讨论了培养成纤维细胞临床应用的过去和当前经验。
