Muso Yumi, Kentarou Ozawa, Itami Satoshi, Yoshikawa Kunihiko
Department of Dermatology, Osaka University, Suita-shi, Osaka, Japan.
J Dermatol. 2007 Jun;34(6):385-6. doi: 10.1111/j.1346-8138.2007.00293.x.
Fixed eruption is a characteristic condition with recurrent an erythematous macule in the same location. Because fixed eruption is caused by medical drugs in the majority of cases, it is not so difficult to identify suspicious material by interview. However, it may be difficult in cases in which food additives are responsible. We report two rare cases of fixed eruption due to quinine contained in tonic water. In case 1, a 37-year-old man had repeated erythema on the same sites after drinking a variety of cocktails. We suspected tonic water as the causative material. Oral challenge test of tonic water was positive and patch test with quinine sulfate was positive also. In case 2, a 24-year-old woman in had noticed that her eruption appeared after drinking liquor, especially cocktails as in case 1. She was also positive upon an oral challenge test of tonic water and in a patch test of quinine sulfate.
固定性药疹是一种特征性疾病，在同一部位反复出现红斑。由于大多数情况下固定性药疹是由药物引起的，通过询问病史来识别可疑物质并不困难。然而，由食品添加剂引起的病例可能会有难度。我们报告两例罕见的因汤力水中含有的奎宁导致的固定性药疹。病例1，一名37岁男性在饮用多种鸡尾酒之后，同一部位反复出现红斑。我们怀疑汤力水是致病物质。汤力水的口服激发试验呈阳性，硫酸奎宁斑贴试验也呈阳性。病例2，一名24岁女性注意到饮用酒类尤其是像病例1中的鸡尾酒之后会出现皮疹。她的汤力水口服激发试验和硫酸奎宁斑贴试验也呈阳性。
