[长期接触苯作业工人T淋巴细胞亚群的变化]
[Changes of T lymphocyte subsets in workers with long-term benzene exposure].
作者信息
Chen Jia-yu, Yu Wei, Liu Wei-wei, Chen Ling-zhen, Wu Jin-ming, Yang Li-jian, Li Yang-qiu
机构信息
Occupational Department of Guangzhou Municipal Twelfth People's Hospital, Guangzhou 510620, China.
出版信息
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007 Apr;25(4):224-6.
OBJECTIVE
To observe the changes of T-lymphocyte subsets in workers with long-term benzene exposure, and further understand the benzene's lymphotoxicity.
METHODS
Blood was sampled from 44 patients with chronic benzene poisoning of different degrees, (mild 22 patients, moderate 14, severe 8) respectively. Twenty-two health benzene exposed workers, and 94 health unexposed workers served as normal control. A total of the phenotype (CD4, CD8) of T lymphocyte in peripheral blood was analyzed by indirect immunofluorescence assay.
RESULTS
Lymphocyte subset analysis showed significantly decreased CD4(+) T lymphocytes, CD4(+)/CD8(+) ratio, except CD8(+) T lymphocytes in benzene exposed groups (P<0.05). Among the four benzene-exposed groups, CD4(+) T lymphocytes and CD4(+)/CD8(+) ratio showed no difference (P>0.05).
CONCLUSION
The primary changes of T-lymphocyte subsets in workers following benzene long-term exposure are the decrease of CD4(+)%, but the changes are not correlated with haematopoietic injury.
目的
观察长期接触苯作业工人T淋巴细胞亚群的变化，进一步了解苯的淋巴细胞毒性。
方法
分别采集44例不同程度慢性苯中毒患者（轻度22例、中度14例、重度8例）、22例接触苯的健康工人及94例未接触苯的健康工人外周血，采用间接免疫荧光法分析外周血T淋巴细胞表型（CD4、CD8）。
结果
淋巴细胞亚群分析显示，苯接触组CD4(+)T淋巴细胞、CD4(+)/CD8(+)比值明显降低，CD8(+)T淋巴细胞除外（P<0.05）。在4个苯接触组中，CD4(+)T淋巴细胞及CD4(+)/CD8(+)比值差异无统计学意义（P>0.05）。
结论
长期接触苯作业工人T淋巴细胞亚群的主要变化是CD4(+)%降低，但与造血损伤无关。
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