Giamarchi A, Padilla F, Crest M, Honore E, Delmas P
Laboratoire de Neurophysiologie Cellulaire, CNRS, UMR 6150, Faculté de Médecine IFR Jean Roche, Marseille Cedex 20, France.
Cell Mol Biol (Noisy-le-grand). 2006 Dec 30;52(8):105-14.
TRPP2 (polycystin-2) is a member of the TRP family of non-selective cation channels that is mutated in human autosomal polycystic kidney disease. It is thought to function together with polycystin-1 (PKD1), a large plasma membrane integral protein, as part of a multiprotein complex involved in transducing Ca2+-dependent mechanosensitive information in renal epithelial cells. TRPP2 has been implicated in Ca2+-dependent pathways in a variety of biological functions and species, including cell proliferation, sperm fertilization, mating behavior and asymmetric gene expression. Although its function as a Ca2+-permeable cation channel is well established, its precise role, regulation and subcellular localization in plasma membrane, endoplasmic reticulum and cilium have remained controversial. The present review summarizes the most pertinent recent evidence regarding the structural and functional properties of TRPP2 channels, focusing on the regulation and physiology of mammalian TRPP2.
TRPP2（多囊蛋白-2）是瞬时受体电位（TRP）家族非选择性阳离子通道的成员，在人类常染色体显性遗传性多囊肾病中发生突变。它被认为与多囊蛋白-1（PKD1，一种大型质膜整合蛋白）共同发挥作用，作为多蛋白复合物的一部分，参与在肾上皮细胞中转导钙离子依赖性机械敏感信息。TRPP2已被证明参与多种生物功能和物种中与钙离子相关的信号通路，包括细胞增殖、精子受精、交配行为和不对称基因表达。尽管其作为钙离子通透阳离子通道的功能已得到充分证实，但其在质膜、内质网和纤毛中的精确作用、调控及亚细胞定位仍存在争议。本综述总结了关于TRPP2通道结构和功能特性的最新相关证据，重点关注哺乳动物TRPP2的调控和生理学。
