多囊蛋白：从机械传感到基因调控

Polycystins: from mechanosensation to gene regulation.

作者信息

Delmas Patrick

机构信息

Laboratoire de Neurophysiologie Cellulaire, CNRS-UMR 6150, Faculté de Médecine, IFR Jean Roche, Bd. Pierre Dramard, 13916 Marseille Cedex 20, France.

出版信息

Cell. 2004 Jul 23;118(2):145-8. doi: 10.1016/j.cell.2004.07.007.

DOI:10.1016/j.cell.2004.07.007

PMID:15260985

Abstract

Polycystin proteins have been suggested to form mechanosensory transduction complexes involved in a variety of biological functions including sperm fertilization, mating behavior, and asymmetric gene expression in different species. Furthermore, their dysfunction is the cause of cyst formation in human kidney disease. This review focuses on the pros and cons of their candidacy as mechanically gated channels and on recent findings that have significantly advanced our physiological insight.

摘要

多囊蛋白已被认为可形成机械感觉转导复合物，参与多种生物学功能，包括不同物种的精子受精、交配行为和不对称基因表达。此外，它们的功能障碍是人类肾脏疾病中囊肿形成的原因。本综述重点关注它们作为机械门控通道候选者的优缺点，以及最近显著推进我们生理认识的研究发现。