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Lean gene and the clock machine.

作者信息

Ramsey Kathryn Moynihan, Bass Joseph

机构信息

Department of Medicine, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA.

出版信息

Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9553-4. doi: 10.1073/pnas.0703516104. Epub 2007 May 29.

DOI:10.1073/pnas.0703516104
PMID:17535891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1887575/
Abstract
摘要

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Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity.昼夜节律性去腺苷酸化酶Nocturnin的缺失赋予了对肝脂肪变性和饮食诱导肥胖的抗性。
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2
Molecular components of the mammalian circadian clock.哺乳动物生物钟的分子组成部分。
Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R271-7. doi: 10.1093/hmg/ddl207.
3
Circadian time keeping: the daily ups and downs of genes, cells, and organisms.昼夜节律计时：基因、细胞和生物体的每日起伏。
Prog Brain Res. 2006;153:271-82. doi: 10.1016/S0079-6123(06)53016-X.
4
The circadian cycle: daily rhythms from behaviour to genes.昼夜节律周期：从行为到基因的每日节律
EMBO Rep. 2005 Oct;6(10):930-5. doi: 10.1038/sj.embor.7400541.
5
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.肝脏X受体在胰岛素介导的Srebp-1c转录激活及肝脏脂肪酸合成刺激中起核心作用。
Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11245-50. doi: 10.1073/pnas.0404297101. Epub 2004 Jul 20.
6
A clockwork web: circadian timing in brain and periphery, in health and disease.一个发条式网络：大脑和外周的昼夜节律，关乎健康与疾病
Nat Rev Neurosci. 2003 Aug;4(8):649-61. doi: 10.1038/nrn1177.
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Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes.小鼠肝脏的全基因组表达分析揭示了受生物钟调控的昼夜节律输出基因。
J Biol Chem. 2003 Oct 17;278(42):41519-27. doi: 10.1074/jbc.M304564200. Epub 2003 Jul 15.
8
Coordinated transcription of key pathways in the mouse by the circadian clock.昼夜节律钟对小鼠关键信号通路的协同转录调控
Cell. 2002 May 3;109(3):307-20. doi: 10.1016/s0092-8674(02)00722-5.
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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.固醇调节元件结合蛋白：肝脏中胆固醇和脂肪酸合成完整程序的激活剂。
J Clin Invest. 2002 May;109(9):1125-31. doi: 10.1172/JCI15593.
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Extensive and divergent circadian gene expression in liver and heart.肝脏和心脏中广泛且不同的昼夜节律基因表达。
Nature. 2002 May 2;417(6884):78-83. doi: 10.1038/nature744. Epub 2002 Apr 21.