Northwestern University, Pancoe-ENH Pavilion Room 4405, 2200 Campus Dr, Evanston, IL 60208, USA.
Circ Res. 2010 Feb 19;106(3):447-62. doi: 10.1161/CIRCRESAHA.109.208355.
The incidence of the metabolic syndrome represents a spectrum of disorders that continue to increase across the industrialized world. Both genetic and environmental factors contribute to metabolic syndrome and recent evidence has emerged to suggest that alterations in circadian systems and sleep participate in the pathogenesis of the disease. In this review, we highlight studies at the intersection of clinical medicine and experimental genetics that pinpoint how perturbations of the internal clock system, and sleep, constitute risk factors for disorders including obesity, diabetes mellitus, cardiovascular disease, thrombosis and even inflammation. An exciting aspect of the field has been the integration of behavioral and physiological approaches, and the emerging insight into both neural and peripheral tissues in disease pathogenesis. Consideration of the cell and molecular links between disorders of circadian rhythms and sleep with metabolic syndrome has begun to open new opportunities for mechanism-based therapeutics.
代谢综合征的发病率代表了一系列在工业化世界中持续增加的疾病。遗传和环境因素都促成了代谢综合征，最近有证据表明，昼夜节律系统和睡眠的改变参与了疾病的发病机制。在这篇综述中，我们强调了临床医学和实验遗传学交叉研究的成果，这些成果指出了内部时钟系统和睡眠的干扰如何构成包括肥胖、糖尿病、心血管疾病、血栓形成甚至炎症在内的疾病的危险因素。该领域令人兴奋的一个方面是行为和生理方法的整合，以及对神经和外周组织在疾病发病机制中的新认识。考虑到昼夜节律和睡眠紊乱与代谢综合征之间的细胞和分子联系，为基于机制的治疗开辟了新的机会。
