Somdas Mehmet A, Li Peter M M C, Whiten Darren M, Eddington Donald K, Nadol Joseph B
Department of Otology and Laryngology, Harvard Medical School/Massachusetts Eye and Ear Infirmary, Boston, Mass., USA.
Audiol Neurootol. 2007;12(5):277-84. doi: 10.1159/000103208. Epub 2007 May 23.
The formation of new bone and fibrous tissue in the human inner ear following cochlear implantation was evaluated by computer-assisted 3-D reconstruction. Seven temporal bones from patients who in life had undergone cochlear implantation were prepared for histological study with the implant in situ. The specimens were sectioned in the axial plane at a thickness of 20 microm. At least every tenth section was digitally reconstructed in three dimensions and volumes of new bone and fibrous tissue were calculated per millimeter length of the cochlea. New bone and fibrous tissue were found in all seven specimens, particularly at the cochleostomy site. In addition, new bone and fibrous tissue had extended to variable lengths along the track of the cochlear implant and in some cases extended beyond the distal end of the implanted electrode. This methodology provides a quantitative tool for evaluation of new bone and fibrous tissue in the inner ear following implantation. This should assist in correlating psychophysical and speech perception tests with intracochlear pathology, evaluating both electrode design and the techniques of preserving residual auditory function.
通过计算机辅助三维重建评估人工耳蜗植入后人内耳新骨和纤维组织的形成。对7例生前接受过人工耳蜗植入的颞骨进行准备，使其植入物原位用于组织学研究。标本在轴平面上以20微米的厚度切片。至少每隔十张切片进行三维数字重建，并计算每毫米耳蜗长度的新骨和纤维组织体积。在所有7个标本中均发现了新骨和纤维组织，特别是在蜗窗造口部位。此外，新骨和纤维组织沿人工耳蜗植入轨迹延伸至不同长度，在某些情况下延伸至植入电极的远端之外。该方法为评估植入后内耳的新骨和纤维组织提供了一种定量工具。这应有助于将心理物理学和言语感知测试与耳蜗内病理学相关联，评估电极设计和保留残余听觉功能的技术。
