Khayyata Said, Bentley Gail, Fregene Tosan A, Al-Abbadi Mousa
Department of Pathology and Internal Medicine, Harper University Hospital, Wayne State University, Detroit, Michigan, USA.
Acta Cytol. 2007 May-Jun;51(3):434-6. doi: 10.1159/000325761.
Extramedullary plasmacytoma of the retroperitoneum is rare. Furthermore, plasmacytoma with anaplastic features can be confused with high grade sarcoma clinically and histologically, particularly when the initial immunohistochemical tumor markers are negative. However, paying attention to cytologic imprint smears can give valuable clues to the correct diagnosis.
A 73-year-old male was admitted to our hospital with a recent history of back pain. Abdominal computed tomography revealed a large retroperitoneal mass (6.8 x 5.1 cm). The initial pathologic evaluation revealed a high grade pleomorphic neoplasm that failed to express multiple epithelial, mesenchymal, lymphoid and melanoma immunohistochemical markers. Subsequent fresh tissue evaluation with touch imprints and immunophenotypic characterization confirmed the plasma cell origin of the tumor. Thorough retrospective review of the touch imprint smears clearly showed the plasmacytic cytologic features. Features of multiple myeloma were essentially absent.
Performing cytologic imprint smears on fresh tissue material may help in making the correct diagnosis and is highly recommended.
腹膜后髓外浆细胞瘤罕见。此外，具有间变特征的浆细胞瘤在临床和组织学上可能与高级别肉瘤混淆，尤其是当最初的免疫组化肿瘤标志物为阴性时。然而，关注细胞学印片涂片可为正确诊断提供有价值的线索。
一名73岁男性因近期背痛入院。腹部计算机断层扫描显示腹膜后有一个大肿块（6.8×5.1厘米）。最初的病理评估显示为高级别多形性肿瘤，该肿瘤未能表达多种上皮、间充质、淋巴和黑色素瘤免疫组化标志物。随后通过触摸印片对新鲜组织进行评估并进行免疫表型特征分析，证实了肿瘤的浆细胞起源。对触摸印片涂片进行全面回顾性检查清楚地显示了浆细胞的细胞学特征。基本不存在多发性骨髓瘤的特征。
对新鲜组织材料进行细胞学印片涂片可能有助于做出正确诊断，强烈推荐使用。
