Bangerter M, Hildebrand A, Waidmann O, Griesshammer M
Department of Medicine III (Hematology, Oncology, Clinical Immunology and Infectious Disease), University of Ulm, Germany.
Acta Cytol. 2000 May-Jun;44(3):287-91. doi: 10.1159/000328466.
Extramedullary plasmacytoma is a rare plasma cell neoplasm. It can occur as the sole manifestation of plasma cell neoplasm, as a metastasis from another extramedullary plasmacytoma, as a solitary plasmacytoma of the bone or as a consequence of multiple myeloma. These plasma cell tumors can occur anywhere and have to be differentiated from other neoplasms, infectious processes and chloroma.
We report the findings of fine needle aspiration cytology (FNAC) in 18 patients with extramedullary plasmacytoma. In six patients extramedullary plasmacytoma was the initial presentation of plasma cell neoplasm. In the remaining 12 patients the tumors occurred under or after treatment of plasma cell disease.
Eleven lesions were located in the skin, seven in the lymph nodes, one in the liver and another in the spleen. Two patients with known diagnoses of plasma cell disease were thought, before FNAC, to have an infection, and two had a histologic diagnosis of non-Hodgkin's lymphoma. In 13 of 18 patients, cytologic smears showed anaplastic plasma cells.
FNAC is a front-line investigative procedure in diagnosing extramedullary plasmacytoma.
髓外浆细胞瘤是一种罕见的浆细胞肿瘤。它可作为浆细胞肿瘤的唯一表现形式出现，也可作为另一处髓外浆细胞瘤的转移灶、骨孤立性浆细胞瘤或多发性骨髓瘤的结果出现。这些浆细胞肿瘤可发生于任何部位，必须与其他肿瘤、感染性病变及绿色瘤相鉴别。
我们报告了18例髓外浆细胞瘤患者的细针穿刺细胞学检查（FNAC）结果。6例患者的髓外浆细胞瘤是浆细胞肿瘤的首发表现。其余12例患者的肿瘤发生于浆细胞疾病治疗期间或之后。
11处病变位于皮肤，7处位于淋巴结，1处位于肝脏，另1处位于脾脏。2例已知诊断为浆细胞疾病的患者在FNAC检查前被认为患有感染，2例经组织学诊断为非霍奇金淋巴瘤。18例患者中有13例的细胞学涂片显示为间变性浆细胞。
FNAC是诊断髓外浆细胞瘤的一线检查方法。
