Lin Dong-Liang, Liu Hsiu-Chuan, Yin Hsin-Ling
Institute of Forensic Medicine, Ministry of Justice, Taipei, Taiwan.
J Anal Toxicol. 2007 Mar;31(2):109-13. doi: 10.1093/jat/31.2.109.
Paramethoxyamphetamine (PMA) and paramethoxymethamphetamine (PMMA) are methoxylated phenylethylamine derivatives that have been banned in Taiwan since December 2005. The case history and pathological and toxicological findings of eight recent PMMA fatalities were investigated. All specimens from these cases were initially identified by an AxSYM fluorescence polarization immunoassay screening test for amphetamines with a 300 ng/mL cutoff. Specimens screened positive were confirmed and quantitated by gas chromatography-mass spectrometry. The mean age of these PMMA-related fatalities was 18.9 +/- 4.4 years in the range of 14-25. Seven (87.5%) of these eight cases were men. The mean, standard deviation, and range of PMA found in the heart blood collected from these 8 cases were 0.213, 0.144, and 0.079-0.489 microg/mL, respectively. The corresponding data for PMMA were 4.312, 4.806, and 1.208-15.824 microg/mL, respectively. Other drugs, such as MDA, MDMA, ketamine, norketamine, hydroxymidazolam, methamphetamine, and pentobarbital, were also found in these cases.
对甲氧基苯丙胺（PMA）和对甲氧基甲基苯丙胺（PMMA）是苯乙胺的甲氧基化衍生物，自2005年12月起在台湾被禁用。对最近8例PMMA致死病例的病史、病理及毒理学发现进行了调查。这些病例的所有标本最初通过AxSYM荧光偏振免疫分析法进行苯丙胺筛查试验，截断值为300 ng/mL。筛查呈阳性的标本通过气相色谱-质谱法进行确认和定量。这些与PMMA相关的死亡病例的平均年龄为18.9±4.4岁，年龄范围在14至25岁之间。这8例病例中有7例（87.5%）为男性。从这8例病例采集的心血中检测到的PMA的平均值、标准差和范围分别为0.213、0.144和0.079 - 0.489μg/mL。PMMA的相应数据分别为4.312、4.806和1.208 - 15.824μg/mL。在这些病例中还发现了其他药物，如MDA、MDMA、氯胺酮、去甲氯胺酮、羟基咪达唑仑、甲基苯丙胺和戊巴比妥。
