Donald Andrew I, Chinthamuneedi Meher P, Spearritt Douglas
Intensive Care Unit, St Vincent's Hospital, Toowoomba, QLD, Australia.
Crit Care Resusc. 2007 Jun;9(2):143-7.
To quantify flow irregularities in drug delivery caused by vertical displacement of syringe pumps.
A bench experiment was performed to quantify the effect of height on pumps used in our intensive care and theatre settings. A standard syringe pump and line set loaded with a dye solution was run through a graduated length of tubing, and the effect of changing pump height quantified by measuring progress down the tubing over time.
A 30 cm elevation produced significant drug delivery boluses - up to seven times the programmed rate at 2mL/h. Delivery rate increased in inverse proportion to the programmed rate, as did the time taken to return to the programmed rate. Lowering the pump 30 cm resulted in no-flow times of up to 180 seconds at a flow rate of 2mL/h - again inversely proportional to programmed rate.
Vertical displacement of a common syringe pump by 30 cm produced significant bolus and cessation phenomena. These findings confirm the observations of previous authors and also demonstrate significant flow irregularities with smaller vertical displacements than previously tested. Further testing with other brands of pumps is required before a solution to this clinically important problem may be approached.
量化注射泵垂直位移导致的药物输送不规则情况。
进行了一项实验台实验，以量化高度对我们重症监护室和手术室中使用的泵的影响。将一个装有染料溶液的标准注射泵和管路装置通过一段有刻度的 tubing，通过测量随时间在 tubing 中的推进情况来量化改变泵高度的影响。
30厘米的抬高产生了显著的药物输送大剂量——在2毫升/小时时高达设定速率的七倍。输送速率与设定速率成反比增加，恢复到设定速率所需的时间也是如此。将泵降低30厘米导致在2毫升/小时的流速下无流量时间长达180秒——同样与设定速率成反比。
普通注射泵垂直位移30厘米会产生显著的大剂量和停止现象。这些发现证实了先前作者的观察结果，并且还表明在比先前测试更小的垂直位移下也存在显著的流量不规则情况。在找到解决这个临床重要问题的方法之前，需要对其他品牌的泵进行进一步测试。
