膳食钙、镁和磷对大鼠环磷酸腺苷排泄及肾钙化的影响。

Influence of dietary Ca, Mg, and P on cyclic-AMP excretion and kidney calcification in the rat.

作者信息

Parker H M, Forbes R M

出版信息

Proc Soc Exp Biol Med. 1976 Jan;151(1):215-20. doi: 10.3181/00379727-151-39177.

Abstract

A series of five experiments was conducted with young male albino rats to investigate effects of various levels of dietary Ca, P and Mg on urinary cAMP excretion and kidney calcification. Urinary cAMP excretion was shown to be directly correlated with injected parathyroid (PT) hormone dose level and to be inversely associated with dietary Ca intake. Thus, cAMP excretion may be presumed to reflect PT activity in the young rat. Magnesium deficiency tended to reduce cAMP excretion, while P excess did not affect it. Each treatment induced kidney calcification. Calcium deficiency increased cAMP excretion irrespective of Mg status, although nephrocalcinosis appeared only in the Mg-deficient animals. These data support the view that nephrocalcinosis of dietary origin in the rat is not mediated by increased PT activity.

摘要

用年轻雄性白化大鼠进行了一系列五项实验，以研究不同水平的膳食钙、磷和镁对尿中环磷酸腺苷（cAMP）排泄及肾脏钙化的影响。结果表明，尿中cAMP排泄与注射甲状旁腺（PT）激素剂量水平直接相关，与膳食钙摄入量呈负相关。因此，可以推测cAMP排泄可能反映了幼鼠的PT活性。镁缺乏倾向于降低cAMP排泄，而磷过量则不影响其排泄。每种处理均诱导了肾脏钙化。钙缺乏会增加cAMP排泄，而与镁状态无关，尽管肾钙沉着症仅出现在缺镁动物中。这些数据支持这样一种观点，即大鼠膳食源性肾钙沉着症不是由PT活性增加介导的。