Rasmussen Niels Henrik, Hansen Lars Kjaersgård, Sahlholdt Lene
Gentofte Hospital, Børneafdeling L, Hellerup.
Ugeskr Laeger. 2007 May 7;169(19):1771-4.
A search of the literature of studies on comorbidity in children with idiopathic and cryptogenic epilepsy and its aetiology revealed few prospective longitudinal studies of evidence class II. There were too few studies on aetiology to determine the causes with certainty, but psychosocial factors seem vital, thus emphasizing the importance of information and support to the child and its family, including siblings. The cognitive and behavioural effect of antiepileptic medicine (other than phenobarbital) seems modest when AED is used monotherapeutically. Likewise, there only seems to be a modest connection between comorbidity and epilepsy-related variables such as age of onset, seizure types, EEG-changes and control of seizures.
一项对有关特发性和隐源性癫痫患儿共病及其病因的研究文献的检索发现,几乎没有II类证据的前瞻性纵向研究。关于病因的研究太少,无法确定确切病因,但心理社会因素似乎至关重要,因此强调了向儿童及其家庭(包括兄弟姐妹)提供信息和支持的重要性。当单一使用抗癫痫药物(苯巴比妥除外)时,抗癫痫药物(除苯巴比妥外)的认知和行为影响似乎不大。同样,共病与癫痫相关变量(如发病年龄、癫痫发作类型、脑电图变化和癫痫发作控制)之间似乎也只有适度的关联。