Stojanovich Ljudmila, Zandman-Goddard Gisele, Pavlovich Sanja, Sikanich Natasa
Department of Internal Medicine, Bezhanijska Kosa University Medical Center, Belgrade University, Serbia and Montenegro.
Autoimmun Rev. 2007 Jun;6(6):421-6. doi: 10.1016/j.autrev.2007.02.007. Epub 2007 Mar 12.
Psychiatric abnormalities are common in systemic lupus erythematosus (SLE) with a prevalence of 17% to 75%, reflecting different methods of patient selection and assessment, the different professional orientation of clinicians, and lack of an accepted consensus for diagnosing active neuropsychiatric lupus (NPSLE). The psychiatric syndromes included in the ACR Neuropsychiatric Lupus Nomenclature Committee criteria are cognitive dysfunction, acute confusional state (delirium), anxiety disorder, mood disorder, and psychosis. In SLE patients, identification of psychiatric phenomena and the generation of a differential diagnosis are crucial. Possible mechanisms include vascular injury and pathogenic antibodies. Treatment strategies are based on small case studies. The purpose of this review is to discuss clinical manifestations, pathogenesis and the present therapeutic options in psychiatric lupus.
精神异常在系统性红斑狼疮（SLE）中很常见，患病率为17%至75%，这反映了患者选择和评估方法的不同、临床医生不同的专业倾向以及缺乏诊断活动性神经精神性狼疮（NPSLE）的公认共识。美国风湿病学会（ACR）神经精神性狼疮命名委员会标准中包含的精神综合征有认知功能障碍、急性意识模糊状态（谵妄）、焦虑症、情绪障碍和精神病。在SLE患者中，识别精神现象并进行鉴别诊断至关重要。可能的机制包括血管损伤和致病性抗体。治疗策略基于小样本病例研究。本综述的目的是讨论精神性狼疮的临床表现、发病机制及目前的治疗选择。
