Mauermann Michelle L, Ryan Matthew L, Moon Joon-Shik, Klein Christopher J
Department of Neurology, Section of Peripheral Nerve, Mayo Clinic College of Medicine, 200 First St. SW, Rochester, MN 55905, United States.
J Neurol Sci. 2007 Sep 15;260(1-2):240-3. doi: 10.1016/j.jns.2007.04.009. Epub 2007 May 29.
Waldenström's macroglobulinemia (WM) is a lymphoplasmacytic disorder with associated monoclonal gammopathy. A wide variety of neuropathies can be associated with WM, but most commonly it is a mild length-dependent sensory neuropathy of unclear etiology. Rituximab is a monoclonal antibody which suppresses mature B-cell populations. It has increasingly been used in wide applications including WM, especially in those cases with severe neuropathy. The highlighted case provides an example of rituximab treatment complication in a WM patient with mild sensory neuropathy that evolved to multiple mononeuropathies with features of systemic vasculitis and unusual conversion of type I to type II cryoglobulinemia.
华氏巨球蛋白血症（WM）是一种伴有单克隆丙种球蛋白病的淋巴浆细胞性疾病。多种神经病变可与WM相关，但最常见的是病因不明的轻度长度依赖性感觉神经病变。利妥昔单抗是一种抑制成熟B细胞群体的单克隆抗体。它越来越广泛地应用于包括WM在内的多种疾病，尤其是在那些患有严重神经病变的病例中。该突出病例提供了一个利妥昔单抗治疗并发症的例子，该WM患者最初患有轻度感觉神经病变，随后发展为具有系统性血管炎特征的多发性单神经病变，并且出现了不寻常的I型冷球蛋白血症向II型冷球蛋白血症的转变。
