植物来源的黄烷醇（-）表儿茶素可增强小鼠的血管生成和空间记忆保持能力。
Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice.
作者信息
van Praag Henriette, Lucero Melanie J, Yeo Gene W, Stecker Kimberly, Heivand Neema, Zhao Chunmei, Yip Ed, Afanador Mia, Schroeter Hagen, Hammerstone John, Gage Fred H
机构信息
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
出版信息
J Neurosci. 2007 May 30;27(22):5869-78. doi: 10.1523/JNEUROSCI.0914-07.2007.
Abstract
Diet and exercise have a profound impact on brain function. In particular, natural nutrients found in plants may influence neuronal survival and plasticity. Here, we tested whether consumption of a plant-derived flavanol, (-)epicatechin, enhances cognition in sedentary or wheel-running female C57BL/6 mice. Retention of spatial memory in the water maze was enhanced by ingestion of (-)epicatechin, especially in combination with exercise. Improved spatial memory was associated with increased angiogenesis and neuronal spine density, but not newborn cell survival, in the dentate gyrus of the hippocampus. Moreover, microarray analysis showed upregulation of genes associated with learning and downregulation of markers of neurodegeneration in the hippocampus. Together, our data show that ingestion of a single flavanol improves spatial memory retention in adult mammals.
摘要
饮食和运动对大脑功能有深远影响。特别是，植物中发现的天然营养物质可能会影响神经元的存活和可塑性。在此，我们测试了食用一种植物源黄烷醇（-）表儿茶素是否能增强久坐或跑步的雌性C57BL/6小鼠的认知能力。摄入（-）表儿茶素可增强水迷宫中空间记忆的保持，尤其是与运动相结合时。空间记忆的改善与海马齿状回中血管生成增加和神经元棘密度增加有关，但与新生细胞存活无关。此外，微阵列分析显示海马体中与学习相关的基因上调，神经退行性变标志物下调。总之，我们的数据表明，摄入单一黄烷醇可改善成年哺乳动物的空间记忆保持。
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