Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging/NIH, Baltimore, MD 21224, USA.
Learn Mem. 2011 Jan 18;18(2):103-7. doi: 10.1101/lm.2001611. Print 2011 Feb.
Physical activity improves learning and hippocampal neurogenesis. It is unknown whether compounds that increase endurance in muscle also enhance cognition. We investigated the effects of endurance factors, peroxisome proliferator-activated receptor δ agonist GW501516 and AICAR, activator of AMP-activated protein kinase on memory and neurogenesis. Mice were injected with GW for 7 d or AICAR for 7 or 14 d. Two weeks thereafter mice were tested in the Morris water maze. AICAR (7 d) and GW improved spatial memory. Moreover, AICAR significantly, and GW modestly, elevated dentate gyrus neurogenesis. Thus, pharmacological activation of skeletal muscle may mediate cognitive effects.
体育活动可促进学习和海马神经发生。目前尚不清楚是否能通过增加肌肉耐力的化合物来增强认知能力。我们研究了耐力因子过氧化物酶体增殖物激活受体 δ 激动剂 GW501516 和 AMP 激活蛋白激酶激活剂 AICAR 对记忆和神经发生的影响。将 GW 注射小鼠 7 天或 AICAR 注射 7 或 14 天。2 周后，将小鼠在 Morris 水迷宫中进行测试。AICAR（7 天）和 GW 改善了空间记忆。此外，AICAR 显著增加，GW 适度增加了齿状回神经发生。因此，骨骼肌的药物激活可能介导认知作用。
