Murphy Debra A, Marelich William D, Rappaport Neil B, Hoffman Dannie, Farthing Charles
Health Risk Reduction Projects, Integrated Substance Abuse Programs, Department of Psychiatry, University of California, Los Angeles, CA 90025-7539, USA.
J Int Assoc Physicians AIDS Care (Chic). 2007 Jun;6(2):113-24. doi: 10.1177/1545109707301243.
A randomized 2-group medication adherence intervention is evaluated with HIV-infected adults (N = 141) assessed at baseline, 3-, and 9-month follow-ups. Cognitive (self-efficacy, behavioral intent), mental health (depression, well-being), and substance use indicators were the outcome measures. In addition, a posttest-only analysis from 3 to 9 months evaluates intervention impact on antiretroviral adherence, measured through Medication Event Monitoring System and pill counts. Compared to the standard care group, the intervention group showed significant increases in adherence self-efficacy and behavioral intent at 3 and 9 months and marginal improvements in mental health. Although the standard care group had higher adherence at 3 months (no baseline data were available prior to intervention), intervention group patients showed significant increases in adherence from 3 to 9 months. Although adherence levels achieved by intervention patients may not be sufficient for virological control, this is one of the first studies to provide promising results of longer term effectiveness of a behavioral adherence intervention.
一项针对感染艾滋病毒的成年人（N = 141）的随机两组药物依从性干预研究在基线、3个月和9个月随访时进行了评估。认知指标（自我效能感、行为意图）、心理健康指标（抑郁、幸福感）和物质使用指标为研究的结果测量指标。此外，仅在3至9个月进行的后测分析评估了干预措施对通过药物事件监测系统和药丸计数测量的抗逆转录病毒药物依从性的影响。与标准护理组相比，干预组在3个月和9个月时的依从性自我效能感和行为意图显著提高，心理健康有边际改善。尽管标准护理组在3个月时的依从性更高（干预前没有基线数据），但干预组患者在3至9个月时的依从性显著提高。尽管干预患者达到的依从性水平可能不足以实现病毒学控制，但这是首批为行为依从性干预的长期有效性提供有希望结果的研究之一。
