Bode Ann M, Dong Zigang
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.
Mol Carcinog. 2007 Aug;46(8):591-8. doi: 10.1002/mc.20348.
The JNK proteins are activated by multiple and diverse stimuli, leading to varied and seemingly contradictory cellular responses. In particular, JNKs have been reported to have a role in the induction of apoptosis, but have also been implicated in enhancing cell survival and proliferation. Thus the JNK proteins seem to represent an archetype of contrariety of intracellular signaling. The opposing roles of JNKs have been attributed to the observation that JNKs activate different substrates based on specific stimulus, cell type or temporal aspects. Because of their analogous expression in apparently almost every tissue, JNK1 and JNK2 have most often been considered to have overlapping or redundant functions. In spite of this assessment, research evidence suggests that the functions of JNKs should be addressed in a manner that differentiates between their precise contributions. Specifically in this review, we examine evidence regarding whether the JNKs proteins might play distinctive roles in cellular processes associated with carcinogenesis.
JNK蛋白可被多种不同的刺激激活，从而导致多样且看似矛盾的细胞反应。特别是，据报道JNK在诱导细胞凋亡中发挥作用，但也与增强细胞存活和增殖有关。因此，JNK蛋白似乎代表了细胞内信号转导矛盾性的一个典型例子。JNK的相反作用归因于这样的观察结果，即JNK根据特定的刺激、细胞类型或时间因素激活不同的底物。由于JNK1和JNK2在几乎每个组织中都有类似的表达，它们最常被认为具有重叠或冗余的功能。尽管有这样的评估，但研究证据表明，JNK的功能应以区分其精确贡献的方式来探讨。具体而言，在本综述中，我们研究了有关JNK蛋白是否可能在与致癌作用相关的细胞过程中发挥独特作用的证据。
