Department of Dermatology, Duke University Medical Center, Durham, NC 27710, USA.
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
Cells. 2020 Apr 2;9(4):857. doi: 10.3390/cells9040857.
The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.
c-Jun N-末端激酶（JNKs）包括 JNK1、JNK2 和 JNK3 三个成员，是丝裂原活化蛋白激酶（MAPK）家族的一个亚家族。JNK 信号通路调节多种细胞过程，包括细胞增殖、分化、存活、凋亡和炎症。JNK 通路的失调与多种免疫紊乱和癌症有关。我们的目的是综述 JNK 蛋白及其在常见皮肤疾病中的上游调节因子和下游效应分子，包括银屑病、皮肤纤维化、硬皮病、基底细胞癌（BCC）、鳞状细胞癌（SCC）和黑色素瘤。
