Environ Health Perspect. 1978 Jun;24:5-10. doi: 10.1289/ehp.78245.
This review outlines the current understanding of ovarian endocrine development and regulation with both physiological and biochemical background to provide a framework applicable to problems concerning environmental agents and ovarian endocrine function. Two approaches are used. First, the endocrine regulation of follicle development and corpus luteum function is considered in the classical sense, i.e., viewing these structures as gonadotropin-responsive units undergoing a programmed sequence of development and differentiation. Secondly, a relatively new area of ovarian physiology concerned with intra-ovarian regulation is explored, since this area holds potential for exploration of the direct effects of toxicological or environmental agents upon gonadal endocrine cells.
这篇综述概述了卵巢内分泌发育和调节的现有理解,既有生理学背景,也有生物化学背景,为涉及环境因子和卵巢内分泌功能的问题提供了一个适用框架。采用了两种方法。首先,从经典意义上考虑了卵泡发育和黄体功能的内分泌调节,即将这些结构视为对促性腺激素有反应的单位,经历一个程序化的发育和分化过程。其次,探讨了卵巢生理学中一个相对较新的领域,即卵巢内调节,因为这个领域有可能探索毒理学或环境因子对性腺内分泌细胞的直接影响。