Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.
Centre for Trophoblast Research, Downing Street, Cambridge, CB2 3EG, UK.
Cell Death Differ. 2021 Jan;28(1):35-51. doi: 10.1038/s41418-020-0565-5. Epub 2020 Jun 3.
Both the proper functioning of the female reproductive tract (FRT) and normal placental development are essential for women's health, wellbeing, and pregnancy outcome. The study of the FRT in humans has been challenging due to limitations in the in vitro and in vivo tools available. Recent developments in 3D organoid technology that model the different regions of the FRT include organoids of the ovaries, fallopian tubes, endometrium and cervix, as well as placental trophoblast. These models are opening up new avenues to investigate the normal biology and pathology of the FRT. In this review, we discuss the advances, potential, and limitations of organoid cultures of the human FRT.
女性生殖道（FRT）的正常功能和正常胎盘发育对于女性的健康、幸福和妊娠结局至关重要。由于体外和体内可用工具的限制，对人类 FRT 的研究一直具有挑战性。最近 3D 类器官技术的发展，模拟了 FRT 的不同区域，包括卵巢、输卵管、子宫内膜和子宫颈的类器官，以及胎盘滋养层。这些模型为研究 FRT 的正常生物学和病理学开辟了新途径。在这篇综述中，我们讨论了人类 FRT 类器官培养的进展、潜力和局限性。
