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泰国中部农村地区与人类免疫缺陷病毒(HIV)相关的隐球菌性脑膜炎——治疗难点与预防策略

Human immunodeficiency virus (HIV) related cryptococcal meningitis in rural central Thailand--treatment difficulties and prevention strategies.

作者信息

Wright P, Inverarity D

机构信息

Manorom Christian Hospital, Manorom, Chainat, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 2007 Jan;38(1):58-61.

PMID:17539247
Abstract

In 2000, cryptococcal meningitis was a common HIV related opportunistic infection in central Thailand requiring inpatient management but few patients suffering from it could afford a full course of treatment once infection had occurred. Since then, the production of generic fluconazole and highly active antiretroviral therapy (HAART) in Thailand (and national guidelines regarding their use) is reducing the incidence of this condition and such a strategy of prevention appears much more effective than treating established disease. There remains a continuing need for health education in the region and the removal of stigma associated with this disease so that earlier detection of HIV infection and the implementation of these national guidelines can have their greatest impact.

摘要

2000年,隐球菌性脑膜炎是泰国中部一种常见的与艾滋病相关的机会性感染,需要住院治疗,但一旦感染发生,很少有患者能够负担得起全程治疗。从那时起,泰国通用型氟康唑的生产和高效抗逆转录病毒疗法(HAART)(以及关于其使用的国家指南)正在降低这种疾病的发病率,而且这种预防策略似乎比治疗已确诊疾病更为有效。该地区仍然持续需要进行健康教育,并消除与这种疾病相关的污名,以便对艾滋病毒感染的早期检测以及这些国家指南的实施能够产生最大影响。

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