艾滋病合并隐球菌性脑膜炎患者抗逆转录病毒治疗后隐球菌免疫重建炎症综合征：一项前瞻性多中心研究
Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: a prospective multicenter study.
作者信息
Sungkanuparph Somnuek, Filler Scott G, Chetchotisakd Ploenchan, Pappas Peter G, Nolen Tracy L, Manosuthi Weerawat, Anekthananon Thanomsak, Morris Michele I, Supparatpinyo Khuanchai, Kopetskie Heather, Kendrick Amy S, Johnson Philip C, Sobel Jack D, Larsen Robert A
机构信息
Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand.
出版信息
Clin Infect Dis. 2009 Sep 15;49(6):931-4. doi: 10.1086/605497.
A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy of the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with cryptococcal meningitis who received highly active antiretroviral therapy (HAART), 13 experienced cryptococcal IRIS. No association between the timing of HAART initiation and the diagnosis of IRIS was identified. Increased baseline serum cryptococcal antigen (CrAg) titer was a risk factor for cryptococcal IRIS.
作为细菌学和真菌学研究组3-01的一项子研究，开展了一项关于隐球菌免疫重建炎症综合征（IRIS）的前瞻性多中心研究。在101例接受高效抗逆转录病毒治疗（HAART）的艾滋病合并隐球菌性脑膜炎患者中，有13例发生了隐球菌性IRIS。未发现开始HAART的时间与IRIS诊断之间存在关联。基线血清隐球菌抗原（CrAg）滴度升高是隐球菌性IRIS的一个危险因素。
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