[利用反义寡核苷酸抑制流感病毒M1蛋白mRNA的体外翻译]
[Suppression of translation in vitro of the mRNA of the M1 protein of influenza virus using antisense oligonucleotides].
作者信息
Vlasov V V, Gorn V V, Nomokonova N Iu, Fokina T N, Iurchenko L V
出版信息
Mol Biol (Mosk). 1991 Sep-Oct;25(5):1332-7.
PMID:1753959
Abstract
Effect of antisense oligonucleotides on the in vitro translation of the influenza virus M1 protein mRNA was investigated. The most efficient arrest of mRNA translation was achieved by simultaneous action of two or three oligonucleotides (14-16-mers) complementary to the juxtaposed sequences in the 5'-terminus of the molecule around and upstream of the initiation codon.
摘要
研究了反义寡核苷酸对流感病毒M1蛋白mRNA体外翻译的影响。通过两种或三种与起始密码子周围及上游分子5'-末端并列序列互补的寡核苷酸（14 - 16聚体）同时作用，实现了mRNA翻译的最有效阻断。
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