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Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

作者信息

Cooke Heather A, Zhang Jian, Griffin Meghan A, Nonaka Koichi, Van Lanen Steven G, Shen Ben, Bruner Steven D

机构信息

Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.

出版信息

J Am Chem Soc. 2007 Jun 27;129(25):7728-9. doi: 10.1021/ja071886a. Epub 2007 Jun 1.

DOI:10.1021/ja071886a
PMID:17539640
Abstract
摘要

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Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.NcsB2作为一种混杂的萘甲酸/辅酶A连接酶的特性，该酶是烯二炔类抗肿瘤抗生素新制癌菌素生物合成所必需的。
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Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.参与烯二炔类抗肿瘤抗生素新制癌菌素生物合成的SAM依赖性O-甲基转移酶NcsB1底物选择性的分子基础。
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