钯催化的咪唑啉酮直接官能团化反应：二溴海兔毒素的合成。
Palladium-catalyzed direct functionalization of imidazolinone: synthesis of dibromophakellstatin.
作者信息
Lu Jianming, Tan Xianghui, Chen Chuo
机构信息
Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA.
出版信息
J Am Chem Soc. 2007 Jun 27;129(25):7768-9. doi: 10.1021/ja072844p. Epub 2007 Jun 1.
Abstract
The direct C-H functionalization of imidazolinone is achieved with Pd(OAc)/NaOAc in DMSO. Dibromophakellstatin can be synthesized in 5 steps with 40% overall yield using this new C-H activation method.
摘要
在二甲基亚砜（DMSO）中，使用醋酸钯（Pd(OAc)）/醋酸钠（NaOAc）实现了咪唑啉酮的直接碳氢键官能团化。利用这种新的碳氢键活化方法，可通过五步合成二溴海兔毒素，总产率为40%。
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