Wang Xiao, Ma Zhiqiang, Wang Xiaolei, De Saptarshi, Ma Yuyong, Chen Chuo
Division of Chemistry, Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA.
Chem Commun (Camb). 2014 Aug 14;50(63):8628-39. doi: 10.1039/c4cc02290d. Epub 2014 May 15.
The pyrrole-imidazole alkaloids are a group of structurally unique and biologically interesting marine sponge metabolites. Among them, the cyclic dimers have caught synthetic chemists' attention particularly. Numerous synthetic strategies have been developed and various biosynthetic hypotheses have been proposed for these fascinating natural products. We discuss herein the synthetic approaches and the biosynthetic insights obtained from these studies.
吡咯 - 咪唑生物碱是一类结构独特且具有生物学意义的海洋海绵代谢产物。其中,环状二聚体尤其引起了合成化学家的关注。针对这些迷人的天然产物,人们已经开发了众多合成策略,并提出了各种生物合成假说。我们在此讨论这些研究中获得的合成方法和生物合成见解。