一种简单的用于仲胺亲电氰化的方法。
A simple method for the electrophilic cyanation of secondary amines.
机构信息
University of Texas Southwestern Medical Center , Department of Biochemistry, 5323 Harry Hines Boulevard, Dallas, Texas 75390, United States.
出版信息
Org Lett. 2014 Jan 3;16(1):247-9. doi: 10.1021/ol403245r. Epub 2013 Dec 6.
Abstract
Bleach oxidizes trimethylsilyl cyanide to generate an electrophilic cyanating reagent that readily reacts with an amine nucleophile. This oxidative N-cyanation reaction allows for the preparation of disubstituted cyanamides from amines without using highly toxic cyanogen halides.
摘要
次氯酸钠将三甲基硅基氰化物氧化，生成亲电的氰化试剂，该试剂可与胺类亲核试剂迅速反应。这种氧化 N-氰化反应可使胺类化合物无需使用剧毒的卤化氰制备二取代氰基酰胺。
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