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从葡萄膜黑色素瘤分泌蛋白组中发现生物标志物：患者血清中gp100和组织蛋白酶D的鉴定

Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum.

作者信息

Pardo María, García Angel, Antrobus Robin, Blanco María José, Dwek Raymond A, Zitzmann Nicole

机构信息

Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom.

出版信息

J Proteome Res. 2007 Jul;6(7):2802-11. doi: 10.1021/pr070021t. Epub 2007 Jun 1.

DOI:10.1021/pr070021t
PMID:17539671
Abstract

There is a necessity to better characterize uveal melanoma (UM) tumors according to their metastasis potential at an early stage. In this study we report the identification of potential biomarkers by a combination of proteomics-related approaches: the characterization of UM cell secretomes, the analysis of UM autoantibodies, and the differential depleted serum proteome analysis. We describe a possible role of cathepsin D, syntenin, and gp100 in UM as potential biomarkers.

摘要

有必要根据葡萄膜黑色素瘤（UM）肿瘤早期的转移潜能对其进行更好的特征描述。在本研究中，我们报告了通过蛋白质组学相关方法的组合来鉴定潜在生物标志物：UM细胞分泌蛋白质组的特征描述、UM自身抗体的分析以及差异去除血清蛋白质组分析。我们描述了组织蛋白酶D、syntenin和gp100在UM中作为潜在生物标志物的可能作用。

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