Liu Y, Shen X, Zhu Y, Xu Y, Cai W, Shen M, Yu R, Wang W
Departments of Clinical Psychology and Psychiatry, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Neurophysiol Clin. 2007 Apr-May;37(2):89-96. doi: 10.1016/j.neucli.2007.03.001. Epub 2007 Apr 2.
The mismatch negativity (MMN) to frequency deviant tones has yielded conflicting results in patients with schizophrenia. This might be because Axis I schizophrenia overlaps with Axis II diagnoses such as paranoid or schizotypal personality disorders. This study was designed to address this issue.
We evaluated the auditory MMN to frequency deviance in 17 patients with paranoid, 15 schizotypal, and 16 antisocial personality disorders. These were compared to 25 healthy subjects.
N1 to both deviant and standard tones was shorter in the paranoid group when compared to healthy controls. MMN latencies were shorter at Fz, Cz, and Pz in the paranoid group when compared to healthy controls, schizotypal, and antisocial groups. MMN amplitudes were higher at Fz and Cz in the schizotypal and antisocial groups when compared to healthy controls and the paranoid group.
Patients with paranoid personality disorder had faster automatic detection of auditory stimuli and of their change, but normal inhibition of irrelevant stimuli. By contrast, patients with schizotypal and antisocial personality disorders had normal discrimination of the auditory stimuli, but might have a deficit in inhibition on irrelevant stimuli. Our results might help differentiate these personality types, and clarify some MMN findings in schizophrenia.
精神分裂症患者对频率偏差音调的失匹配负波（MMN）研究结果存在矛盾。这可能是因为I轴精神分裂症与II轴诊断（如偏执型或分裂型人格障碍）存在重叠。本研究旨在解决这一问题。
我们评估了17例偏执型人格障碍患者、15例分裂型人格障碍患者和16例反社会型人格障碍患者对频率偏差的听觉MMN。并将其与25名健康受试者进行比较。
与健康对照组相比，偏执型人格障碍组对偏差音调和标准音调的N1波潜伏期均较短。与健康对照组、分裂型人格障碍组和反社会型人格障碍组相比，偏执型人格障碍组在Fz、Cz和Pz电极处的MMN潜伏期较短。与健康对照组和偏执型人格障碍组相比，分裂型人格障碍组和反社会型人格障碍组在Fz和Cz电极处的MMN波幅较高。
偏执型人格障碍患者对听觉刺激及其变化具有更快的自动检测能力，但对无关刺激的抑制正常。相比之下，分裂型人格障碍和反社会型人格障碍患者对听觉刺激的辨别正常，但可能在抑制无关刺激方面存在缺陷。我们的研究结果可能有助于区分这些人格类型，并阐明精神分裂症中一些MMN的研究发现。
