来自索氏大戟的具有促神经突生长活性的鞘脂类。

Sphingolipids with neuritogenic activity from Euphorbia sororia.

作者信息

Zhang Wei-Ku, Xu Jie-Kun, Zhang Xiao-Qi, Yao Xin-Sheng, Ye Wen-Cai

机构信息

Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China.

出版信息

Chem Phys Lipids. 2007 Aug;148(2):77-83. doi: 10.1016/j.chemphyslip.2007.04.008. Epub 2007 Apr 21.

DOI:10.1016/j.chemphyslip.2007.04.008

PMID:17540352

Abstract

Two groups of sphingolipids 1 and 2 were isolated from the aerial parts of Euphorbia sororia. On the basis of spectroscopic data, chemical methods and GC-MS analysis, the structures of 1 and 2 were characterized as 1-O-beta-D-glucopyranosyl-(2S,3S,4R,8Z)-2-[(2'R)-2'-hydroxydocosanoyl approximately hexacosanoyl, octacosanoyl amino]-1,3,4-octadecanetriol-8-ene and (2S,3S,4R,8E)-2-[(2'R)-2'-hydroxyeicosanoyl approximately hexacosanoyl amino]-1,3,4-octadecanetriol-8-ene, respectively. Both of them exhibited marked neuritogenic activity on the rat pheochromocytoma PC12 cell line.

摘要

从索氏大戟地上部分分离出两组鞘脂1和2。基于光谱数据、化学方法和气相色谱-质谱分析，1和2的结构分别被表征为1-O-β-D-吡喃葡萄糖基-(2S,3S,4R,8Z)-2-[(2'R)-2'-羟基二十二烷酰基~~二十六烷酰基、二十八烷酰基氨基]-1,3,4-十八碳三烯-8-烯和(2S,3S,4R,8E)-2-[(2'R)-2'-羟基二十烷酰基~~二十六烷酰基氨基]-1,3,4-十八碳三烯-8-烯。它们在大鼠嗜铬细胞瘤PC12细胞系上均表现出显著的促神经突生长活性。