Porton Barbara, Wetsel William C
Nathan Kline Institute for Psychiatric Research and Department of Psychiatry, New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, New York 10962, United States.
Schizophr Res. 2007 Aug;94(1-3):366-70. doi: 10.1016/j.schres.2007.04.016. Epub 2007 May 30.
We analyzed the expression of a presynaptic protein, synapsin III, in individuals with schizophrenia. Since levels of synapsin III were previously found to be significantly reduced in the hippocampus of individuals with schizophrenia, we examined another brain region believed to be a major locus of dysfunction in schizophrenia, the dorsolateral prefrontal cortex (DLPFC). Western blot analyses using tissue obtained from the Stanley Foundation Neuropathology Consortium revealed that synapsin III levels were significantly decreased in the DLPFC of individuals with schizophrenia compared to controls. These findings are consistent with growing evidence of presynaptic abnormalities and prefrontal cortical dysfunction in schizophrenia.
我们分析了精神分裂症患者中一种突触前蛋白——突触结合蛋白III的表达情况。由于先前发现精神分裂症患者海马体中突触结合蛋白III的水平显著降低，我们检查了另一个被认为是精神分裂症功能障碍主要部位的脑区——背外侧前额叶皮质（DLPFC）。使用从斯坦利基金会神经病理学联盟获得的组织进行的蛋白质印迹分析显示，与对照组相比，精神分裂症患者DLPFC中突触结合蛋白III的水平显著降低。这些发现与精神分裂症中突触前异常和前额叶皮质功能障碍的证据越来越多相一致。
