Maintz Laura, Novak Natalija
Department of Dermatology, Sigmund-Freud-Str. 25, 53105 Bonn, University of Bonn.
Eur J Dermatol. 2007 Jul-Aug;17(4):267-83. doi: 10.1684/ejd.2007.0200. Epub 2007 Jun 1.
Atopic eczema (AE) is a multifactorial chronic inflammatory skin disease characterized by pruritic, typically distributed eczematous skin lesions. Deficiencies in innate and adaptive immunity based on a genetic predisposition result in skin barrier dysfunction with hyperreactivity to environmental stimuli and susceptibility to skin infections which influence the course and severity of AE. In this review, we provide an overview of the complex pathophysiology of AE with a focus on recent advances published in this field.
特应性皮炎（AE）是一种多因素慢性炎症性皮肤病，其特征为瘙痒，典型分布的湿疹性皮肤病变。基于遗传易感性的先天性和适应性免疫缺陷导致皮肤屏障功能障碍，对环境刺激反应过度，易患皮肤感染，这些都会影响AE的病程和严重程度。在本综述中，我们概述了AE复杂的病理生理学，重点关注该领域最近发表的进展。
