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白芷对2,4-二硝基氯苯诱导的小鼠模型特应性皮炎样皮肤损伤的影响。

Effects of Angelicae dahuricae Radix on 2, 4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in mice model.

作者信息

Ku Jin Mo, Hong Se Hyang, Kim Hyo In, Seo Hye Sook, Shin Yong Cheol, Ko Seong-Gyu

机构信息

Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, 02447, Korea.

Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 1 Hoegi, Seoul, 130-701, Korea.

出版信息

BMC Complement Altern Med. 2017 Feb 7;17(1):98. doi: 10.1186/s12906-017-1584-8.

DOI:10.1186/s12906-017-1584-8
PMID:28173791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5297152/
Abstract

BACKGROUND

Atopic dermatitis (AD) is an inflammatory, chronically relapsing, and intensively pruritic skin disease that affect 10-30% of the global population. Angelicae dahuricae Radix (ADR) has been reported to be anti-inflammatory in Korean Medicine. In the present study, we investigated whether ADR suppresses the progression of AD in animal model.

METHODS

AD was induced by 2, 4-Dinitrochlorobenzene (DNCB). ADR was orally administered to mice to study the effect of ADR on AD. Histological Analysis, immunohistochemistry, blood analysis, RT-PCR, and ELISA assay were performed.

RESULTS

ADR significantly suppressed AD-like symptoms in BALB/c mice: ADR decreased skin thickness and spleen weight of mice. ADR reduced infiltration of mast cells, inflammatory cells and CD4+ cells into mouse skin. ADR lowered the number of WBCs in the blood of mice. ADR reduced the levels of IgE, IL-6, IL-10 and IL-12 in mice serum. ADR down-regulated mRNA expression of IL-4, IL-6 and TNF-α in mouse skin tissue.

CONCLUSION

Our present study clearly indicates that ADR suppresses the progression of AD induced by DNCB in BALB/c mice. This suggests that ADR might be a useful drug for the treatment of AD.

摘要

背景

特应性皮炎（AD）是一种炎症性、慢性复发性且瘙痒剧烈的皮肤病，影响全球10%-30%的人口。在韩医学中，白芷已被报道具有抗炎作用。在本研究中，我们调查了白芷是否能抑制动物模型中特应性皮炎的进展。

方法

用2,4-二硝基氯苯（DNCB）诱导特应性皮炎。给小鼠口服白芷以研究其对特应性皮炎的影响。进行了组织学分析、免疫组化、血液分析、逆转录聚合酶链反应（RT-PCR）和酶联免疫吸附测定（ELISA）。

结果

白芷显著抑制BALB/c小鼠的特应性皮炎样症状：白芷降低了小鼠的皮肤厚度和脾脏重量。白芷减少了肥大细胞、炎性细胞和CD4+细胞向小鼠皮肤的浸润。白芷降低了小鼠血液中白细胞的数量。白芷降低了小鼠血清中免疫球蛋白E（IgE）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）和白细胞介素-12（IL-12）的水平。白芷下调了小鼠皮肤组织中白细胞介素-4（IL-4）、白细胞介素-6和肿瘤坏死因子-α（TNF-α）的信使核糖核酸（mRNA）表达。

结论

我们目前的研究清楚地表明，白芷抑制了BALB/c小鼠中由DNCB诱导的特应性皮炎的进展。这表明白芷可能是一种治疗特应性皮炎的有效药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/85ddb6b40582/12906_2017_1584_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/ec92154e8cf2/12906_2017_1584_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/5d2054707973/12906_2017_1584_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/b0879d6c4abc/12906_2017_1584_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/34daae33c25e/12906_2017_1584_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/8729856c70bf/12906_2017_1584_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/85ddb6b40582/12906_2017_1584_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/ec92154e8cf2/12906_2017_1584_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/aced8969ec6f/12906_2017_1584_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/5d2054707973/12906_2017_1584_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/b0879d6c4abc/12906_2017_1584_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/34daae33c25e/12906_2017_1584_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/8729856c70bf/12906_2017_1584_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ce/5297152/85ddb6b40582/12906_2017_1584_Fig7_HTML.jpg

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