Rancé Fabienne, Boguniewicz Mark, Lau Susanne
Hôpital des Enfants, Toulouse, France.
Pediatr Allergy Immunol. 2008 Aug;19 Suppl 19:17-25. doi: 10.1111/j.1399-3038.2008.00764.x.
Atopic eczema (AE) is a chronic inflammatory skin disease characterized by pruritus, dry skin and an ongoing course of exacerbations and remissions. AE is a common disorder in children with a worldwide cumulative prevalence of 15-20% in this age group. AE has a strong familial predisposition. While AE is a complex disease with multiple gene involvement, recent interest has focused on genes involved in skin barrier/epidermal differentiation and in immune response/host defense. Recent developments and future directions on pathogenesis, diagnosis, natural course and prognosis are discussed.
特应性皮炎（AE）是一种慢性炎症性皮肤病，其特征为瘙痒、皮肤干燥以及病情持续反复加重。AE在儿童中是一种常见疾病，在全球该年龄组中的累计患病率为15% - 20%。AE具有很强的家族易感性。虽然AE是一种涉及多个基因的复杂疾病，但最近的研究兴趣集中在参与皮肤屏障/表皮分化以及免疫反应/宿主防御的基因上。本文讨论了AE在发病机制、诊断、自然病程和预后方面的最新进展及未来方向。
