Hall I P, Sayers I
Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK.
Eur Respir J. 2007 Jun;29(6):1239-45. doi: 10.1183/09031936.00088206.
Pharmacogenetic approaches provide the opportunity to improve prescribing for asthmatic patients in order to optimise efficacy and prevent side-effects. Currently, there are comprehensive data available on the extent of genetic variation in the human genome that will further this area of research. However, less is known about the functional consequences of many of the identified polymorphisms in genes whose products may predict drug efficacy. In addition, there is a shortage of well-designed, adequately powered clinical studies in this area. This series summarises the current state of knowledge and identifies areas for further research.
药物遗传学方法为改善哮喘患者的用药处方提供了机会，以优化疗效并预防副作用。目前，关于人类基因组中基因变异程度已有全面数据，这将推动该研究领域的发展。然而，对于许多已鉴定出的多态性，其所在基因产物可能预测药物疗效，但我们对这些多态性的功能后果了解较少。此外，该领域缺乏设计良好、样本量充足的临床研究。本系列总结了当前的知识状况，并确定了进一步研究的领域。
