Shechter Ravid, Ziv Yaniv, Schwartz Michal
Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel.
Stem Cells. 2007 Sep;25(9):2277-82. doi: 10.1634/stemcells.2006-0705. Epub 2007 May 31.
Neural stem/progenitor cells are known to exist in the intact spinal cord, but the presence of newly formed neurons during adulthood has not been documented there to date. Here, we report the appearance of newly formed neurons under normal physiological conditions. These neurons are immature, express a GABAergic phenotype, and are primarily located in the dorsal part of the spinal cord. This localization appeared to be mediated by stromal-derived factor-1/CXC-chemokine receptor-4 signaling in the dorsal region. The extent of spinal cord neurogenesis was found to be greatly influenced by immune system integrity and in particular by myelin-specific T cells. These observations provide evidence for in vivo spinal cord neurogenesis under nonpathological conditions and introduce novel mechanisms regulating adult spinal cord plasticity.
已知神经干细胞/祖细胞存在于完整的脊髓中，但迄今为止，尚未在成年期脊髓中记录到新形成的神经元的存在。在此，我们报告了在正常生理条件下新形成神经元的出现。这些神经元不成熟，表达γ-氨基丁酸能表型，主要位于脊髓背侧。这种定位似乎是由背侧区域的基质细胞衍生因子-1/CXC趋化因子受体-4信号介导的。发现脊髓神经发生的程度受免疫系统完整性，特别是髓鞘特异性T细胞的极大影响。这些观察结果为非病理条件下体内脊髓神经发生提供了证据，并引入了调节成年脊髓可塑性的新机制。
