Hasegawa Takao, Ako Junya, Ikeno Fumiaki, Waseda Katsuhisa, Suzuki Yoriyasu, Honda Yasuhiro, Fitzgerald Peter J
Center for Research in Cardiovascular Interventions, Stanford University, Stanford, California 94305, USA.
J Invasive Cardiol. 2007 Jun;19(6):244-6.
To compare the difference of strut distribution between two clinically available drug-eluting stent platforms (Bx Velocity and Express II stents) using intravascular ultrasound (IVUS).
Nonuniform strut distribution (NSD) has been shown to be associated with increased intimal hyperplasia after drug-eluting stent implantation.
IVUS imaging was performed on Bx Velocity (n = 6) and Express II stents (n = 6) after inflation pressures of 10, 16, and 26 atm in a bench test model. Percent NSD was defined as the length of segments with NSD (interstrut angle > 90 degrees) divided by stent length. NSD was also assessed in postprocedure IVUS images in 53 clinical cases (32 Cypher, 21 Taxus) using 3-dimensional IVUS analysis.
Frequency of NSD segment and %NSD were lower in Bx Velocity stents than in Express II stents at the inflation pressures of 16 and 26 atm (%NSD: 16 atm, 0% vs. 13.8 +/- 9.4%; p < 0.005; 26 atm, 1.1 +/- 2.6% vs. 19.9 +/- 6.9% p < 0.0001). In postprocedural images from clinical cases, the frequency of NSD segment and %NSD were lower in Cypher stents than in Taxus stents (%NSD: 0.5 +/- 1.6 vs. 6.8 +/- 7.2; p < 0.0001).
NSD segment was observed less in Bx Velocity stents than in Express II stents.
使用血管内超声（IVUS）比较两种临床可用药物洗脱支架平台（Bx Velocity和Express II支架）的支架分布差异。
已表明药物洗脱支架植入后，不均匀支架分布（NSD）与内膜增生增加有关。
在体外试验模型中，对Bx Velocity支架（n = 6）和Express II支架（n = 6）分别施加10、16和26个大气压的膨胀压力后进行IVUS成像。NSD百分比定义为存在NSD的节段长度（支架间隙角度> 90度）除以支架长度。还使用三维IVUS分析对53例临床病例（32例Cypher，21例Taxus）的术后IVUS图像进行NSD评估。
在16和26个大气压的膨胀压力下，Bx Velocity支架的NSD节段频率和NSD百分比低于Express II支架（NSD百分比：16个大气压时，0%对13.8 +/- 9.4%；p < 0.005；26个大气压时，1.1 +/- 2.6%对19.9 +/- 6.9%，p < 0.0001）。在临床病例的术后图像中，Cypher支架的NSD节段频率和NSD百分比低于Taxus支架（NSD百分比：0.5 +/- 1.6对6.8 +/- 7.2；p < 0.0001）。
与Express II支架相比，Bx Velocity支架中观察到的NSD节段较少。
