(3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin: a new ramulosin derivative from a marine-derived sterile mycelium.
作者信息
El-Beih Ahmed Atef, Kato Hikaru, Ohta Tomihisa, Tsukamoto Sachiko
机构信息
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2007 Jun;55(6):953-4. doi: 10.1248/cpb.55.953.
PMID:17541203
Abstract
(3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin (1) was isolated from a culture of a sterile mycelium, which was derived from the green alga, Codium fragile, along with (-)-5-methylmellein (2), (-)-5-hydroxymethylmellein (3), and (-)-(3R,4R)-cis-4-hydroxy-5-methylmellein (4). The absolute configuration of 1 was determined by the NMR data along with the lactone sector rule by circular dichroism (CD). Compound 1 exhibited moderate cytotoxic activity against HeLa cells.
摘要
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