一株热枝瑚菌 Xylaria sp. cfcc 87468 的两个新次生代谢产物。

Two new secondary metabolites from Xylaria sp. cfcc 87468.

机构信息

Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China.

出版信息

Molecules. 2014 Jan 20;19(1):1250-7. doi: 10.3390/molecules19011250.

DOI:10.3390/molecules19011250

PMID:24448065

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6270958/

Abstract

A new isocoumarin glycoside, 3R-(+)-5-O-[6'-O-acetyl]-α-D-glucopyranosyl-5-hydroxymellein (1), and a new phenylethanol glycoside, (-)-phenylethyl-8-O-α-L-rhamno-pyranoside (2), were isolated from the ethyl acetate extract of the fungus Xylaria sp. cfcc 87468, together with five known steroids, β-sitosterol (3), stigmast-4-en-3-one (4), ergosterol (5), (22E)-cholesta-4,6,8(14),22-tetraen-3-one (6), and 4α-methyl- ergosta-8(14),24(28)-dien-3β-ol (7). The structures of compounds 1 and 2 were elucidated by MS, extensive 1D and 2D NMR spectroscopy, and the circular dichroism (CD) spectroscopy.

摘要

从真菌 Xylaria sp. cfcc 87468 的乙酸乙酯提取物中分离得到了一种新的异香豆素糖苷，3R-(+)-5-O-[6'-O-乙酰基]-α-D-吡喃葡萄糖基-5-羟甲氧基色满（1），以及一种新的苯乙醇糖苷，(-)-苯乙基-8-O-α-L-鼠李吡喃糖苷（2），此外还有五种已知甾体化合物，β-谷甾醇（3）、豆甾-4-烯-3-酮（4）、麦角甾醇（5）、(22E)-胆甾-4,6,8(14),22-四烯-3-酮（6）和 4α-甲基-麦角甾-8(14),24(28)-二烯-3β-醇（7）。通过 MS、广泛的 1D 和 2D NMR 光谱以及圆二色性（CD）光谱确定了化合物 1 和 2 的结构。