患有输卵管阻塞或既往有异位妊娠史的巴西女性中沙眼衣原体抗体的高滴度。
High titers of Chlamydia trachomatis antibodies in Brazilian women with tubal occlusion or previous ectopic pregnancy.
作者信息
Machado A C S, Guimarães E M B, Sakurai E, Fioravante F C R, Amaral W N, Alves M F C
机构信息
Department of Microbiology, Immunology, Parasitology, and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil.
出版信息
Infect Dis Obstet Gynecol. 2007;2007:24816. doi: 10.1155/2007/24816. Epub 2007 May 17.
OBJECTIVE
To evaluate serum chlamydia antibody titers (CATs) in tubal occlusion or previous ectopic pregnancy and the associated risk factors.
METHODS
The study population consisted of 55 women wih tubal damage and 55 parous women. CAT was measured using the whole-cell inclusion immunofluorescence test and cervical chlamydial DNA detected by PCR. Odds ratios were calculated to assess variables associated with C. trachomatis infection.
RESULTS
The prevalence of chlamydial antibodies and antibody titers in women with tubal occlusion or previous ectopic pregnancy was significantly higher (P < .01) than in parous women. Stepwise logistic regression analysis showed that chlamydia IgG antibodies were associated with tubal damage and with a larger number of lifetime sexual partners.
CONCLUSIONS
Chlamydia antibody titers were associated with tubal occlusion, prior ectopic pregnancy, and with sexual behavior, suggesting that a chlamydia infection was the major contributor to the tubal damage in these women.
目的
评估输卵管阻塞或既往有异位妊娠史女性的血清衣原体抗体滴度（CATs）及其相关危险因素。
方法
研究人群包括55名输卵管受损女性和55名经产妇。采用全细胞包涵体免疫荧光试验检测CAT，通过聚合酶链反应（PCR）检测宫颈衣原体DNA。计算比值比以评估与沙眼衣原体感染相关的变量。
结果
输卵管阻塞或既往有异位妊娠史女性的衣原体抗体患病率和抗体滴度显著高于经产妇（P <.01）。逐步逻辑回归分析表明，衣原体IgG抗体与输卵管损伤及一生中性伴侣数量较多有关。
结论
衣原体抗体滴度与输卵管阻塞、既往异位妊娠及性行为有关，提示衣原体感染是这些女性输卵管损伤的主要原因。
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