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布卡武（刚果民主共和国）细菌性阴道病、沙眼衣原体感染与输卵管性不孕的相关性研究。

Association between bacterial vaginosis, Chlamydia trachomatis infection and tubal factor infertility in Bukavu, Democratic Republic of Congo.

机构信息

Faculty of Medicine, Université Catholique de Bukavu, Bukavu, Democratic Republic of the Congo.

Department of Obstetrics and Gynecology, Hôpital Provincial Général de Référence de Bukavu, Bukavu, Democratic Republic of Congo.

出版信息

BMC Infect Dis. 2024 May 10;24(1):480. doi: 10.1186/s12879-024-09379-w.

DOI:10.1186/s12879-024-09379-w
PMID:38730346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11083818/
Abstract

BACKGROUND

Tubal factor infertility (TFI) is common in sub-Saharan Africa and often secondary to pelvic inflammatory disease (PID). Anaerobes associated with bacterial vaginosis (BV) are also found in PIDs widely dominated by Chlamydia trachomatis (C. trachomatis), whose role in TFI is better demonstrated than that of BV.

OBJECTIVES

To determine the prevalence of BV and C. trachomatis and to investigate the association between BV, C. trachomatis and TFI.

METHODS

We included 137 patients treated for infertility between January 2020 and November 2021. Cases were defined as women with infertility aged 18-45 years presenting with TFI (n = 52), and controls as infertile women in the same age groups without TFI (n = 85). Data on social habits, life style and infertility parameters were collected, and we performed screening for BV and C. trachomatis. Multiple regression was used to measure associations.

RESULTS

The prevalence of BV and C. trachomatis was 42.3% (58/137) and 23.4% (32/137), respectively. BV (61.5% vs 30.6%, p<0.001) and C. trachomatis (48.1 vs 8.2%, p<0.001) were more frequent in cases of TFI. BV and C. trachomatis increased the risk of TFI approximately 4-fold [aOR: 3.77 (1.61-8.83), p=0.002] and 14-fold [aOR: 13.77 (4.59-41.27), p<0.001], respectively.

CONCLUSION

BV and C. trachomatis infection are strongly associated with TFI in Bukavu. Prevention and screening should be implemented to reduce the risk of TFI.

摘要

背景

输卵管性不孕（TFI）在撒哈拉以南非洲很常见，通常继发于盆腔炎（PID）。细菌性阴道病（BV）相关的厌氧菌也广泛存在于沙眼衣原体（C. trachomatis）为主的 PID 中，其在 TFI 中的作用比 BV 更为明显。

目的

确定 BV 和 C. trachomatis 的流行率，并研究 BV、C. trachomatis 与 TFI 之间的关联。

方法

我们纳入了 2020 年 1 月至 2021 年 11 月期间因不孕接受治疗的 137 名患者。病例组定义为年龄在 18-45 岁的 TFI 不孕患者（n=52），对照组为同年龄段无 TFI 的不孕患者（n=85）。收集社会习惯、生活方式和不孕参数等数据，并进行 BV 和 C. trachomatis 的筛查。采用多元回归分析测量关联。

结果

BV 和 C. trachomatis 的流行率分别为 42.3%（58/137）和 23.4%（32/137）。TFI 病例组的 BV（61.5% vs 30.6%，p<0.001）和 C. trachomatis（48.1% vs 8.2%，p<0.001）更为常见。BV 和 C. trachomatis 使 TFI 的风险增加了约 4 倍[aOR：3.77（1.61-8.83），p=0.002]和 14 倍[aOR：13.77（4.59-41.27），p<0.001]。

结论

BV 和 C. trachomatis 感染与布卡武的 TFI 密切相关。应实施预防和筛查措施，以降低 TFI 的风险。