Cave T A, Evans H, Hargreaves J, Blunden A S
Cave Referrals, Sandwell, 7 Hectors Stones, Woolavington, Somerset TA7 8EG, UK.
J Small Anim Pract. 2007 Sep;48(9):522-6. doi: 10.1111/j.1748-5827.2006.00311.x. Epub 2007 Jun 2.
A case of metabolic epidermal necrosis associated with a pancreatic carcinoma is described. Normoglycaemia, reduced serum fructosamine, and hypoaminoacidaemia were identified. Hyperinsulinaemia and hyperglucagonaemia were documented. Immunohistochemistry documented strong tumour expression of both insulin and glucagon supporting combined paraneoplastic production of both hormones by the tumour. Enteral protein and fatty acid supplementation and parenteral amino acid supplementation proved ineffective. Metastasis to regional lymph nodes was identified and the patient was euthanased.
描述了一例与胰腺癌相关的代谢性表皮坏死病例。发现血糖正常、血清果糖胺降低和低氨基酸血症。记录到高胰岛素血症和高胰高血糖素血症。免疫组织化学显示肿瘤强烈表达胰岛素和胰高血糖素，支持肿瘤副肿瘤性联合产生这两种激素。肠内蛋白质和脂肪酸补充以及肠外氨基酸补充均无效。发现有区域淋巴结转移，患者实施了安乐死。
